Elucidations

In this episode, we are joined by Lainie Ross (University of Rochester Medical Center) and (once again!) Christos Lazaridis (UChicago Medicine), this time to talk about the different ways of defining death.In our previous episode with Christos, we talked about death and the vexed history of attempts to define it. Prior to the advent of modern life support technology in the 1950s, it was usually enough to check whether a person had a heartbeat and could breathe to determine whether they were dead. But once machines were invented that could breathe and circulate blood in patients whose lungs or hearts were failing, a new moral conundrum was born: how do you decide whether a medical patient is dead when it is now possible to keep their lungs breathing and their heart beating indefinitely?In this episode, our distinguished guests talk about the actual criteria that physicians use to determine whether a patient is dead, as well as some possible criteria that no one has tried applying but which some doctors think would be more appropriate. Furthermore, Lainie Ross argues that every person has the right to choose which criteria will be used to determine whether they are dead. These two topics interact in interesting ways.For example, I might have a strong preference for my doctor to pronounce me dead only if I have permanently lost all consciousness, even if I can still spontaneously breathe. Although we currently have no good method of objectively measuring whether a patient has permanently lost consciousness, Dr. Ross argues that I have the moral right to sign an agreement stating my preferences. Specifically: the agreement could state that if, in the future, the technology for determining whether someone has permanently lost consciousness gets invented, and, at that time, I have permanently lost consciousness, then I should be declared dead. On the flipside, some patients prefer a stricter criterion, often for religious reasons. Perhaps it is my religious belief that if I am breathing, then I should be considered to be alive. Lainie Ross argues that in that case, I have the moral right to sign an agreement stating that that is the criterion that doctors will use on me, in the event that I lose consciousness but am still able to spontaneously breathe.As of right now, people only have the legal right to sign these types of agrreements in a handful of states in the US. Join us for this episode as Christos Lazaridis and Lainie Ross argue for making this legal right more widespread! Hosted on Acast. See acast.com/privacy for more information.

In this episode, Matt sits down with Christos Lazaridis (University of Chicago Medicine) to chat about what brain death is and whether brain death should count as, like, death death.Modern life support technology really hits its stride in the 1960s, allowing doctors to buy themselves more time to save their patients by connecting them to machines that can assist with breathing, blood oxygenation and/or heart pumping. But the flipside to that incredible technological breakthrough was that the medical community now needed to get more precise about the moment at which a person goes from being alive to being dead. After all, what had previously been a quick window between the two was now, due to life support technology, happening in extreme slow motion. In addition, organ transplanation was becoming more and more commonplace, meaning that it was no longer as simple as saying e.g. ‘I count someone as dead just in case their heart has stopped.’By the early 80s, the United States had settled on a standard definition for when someone counts as dead, which states that a person is dead if they have either permanently lost consciousness or permanently lost the ability to breathe and pump blood with their heart. That criterion makes certain life-saving practices possible; for example, it legally feasible for organ transplantation to begin once a patient has fallen into an irreversible coma, provided they agreed to donate their organs in advance.But should a person really count as dead just because they fell into an irreversible coma? We call that condition ‘brain death’, or sometimes the wordier ‘death by neurological criteria’, and we legally count it as a full death. Critics of the notion of brain death say that it should not count as death, because a person in this condition is still biologically alive. Their argument is that saying a person in this condition is dead is just a story we’re telling ourselves.In this episode, Christos Lazaridis—who is a practicing neurointensivist—argues that even if that is a story we’re telling ourselves, that’s fine, because this is a corner case in which it makes sense for the social/legal status of being dead to come apart from the biological status of being dead. Tune in to hear why he thinks this is the case! Hosted on Acast. See acast.com/privacy for more information.

In this episode, Matt talks to Gabriella Gonzalez about how basic concepts from the branch of math known as abstract algebra can help us simplify our computer programs and organize our thoughts.Algebra. That thing they make us do in school. What was that again? Oh yeah, that’s right; it’s where you get to manipulate equations containing variables. Like, if I have an equation that looks like this:2⋅x = 16Then I can divide both sides by two and get a new version where x stands alone, i.e. solve for x:(2⋅x) / 2 = 16 / 2x = 8If you took algebra in school, you might remember learning a bunch of tricks for pushing parts of equations around to get one of the variables to appear only on one side and thus solve for it. Being able to solve for variables in equations proves useful for lots of things: like, if you can translate a word problem into one of those equations, finding the answer is often as simple as tinkering with the equation in some obvious way.Abstract algebra is somewhat similar in that it also involves manipulating equations containing variables, except the twist is that now you aren’t necessarily manipulating numbers anymore. The variables can stand for something else, and there are more general versions of plus-like, times-like, etc. operations that you can do on these other things. You might be wondering: what on earth could a variable in an equation stand for other than a number? Well, in this episode, Gabriella Gonzalez gives a bunch of examples. You can have equations for cooking recipes, for computer programs, for transactions performed on databases, and for regular expressions. (A regular expression is a special type of computer program for identifying strings that fit a particular pattern and pulling information out of them.)Gonzalez then goes on to argue that the point of all this is to avoid re-inventing the wheel. Often, when you write a computer program to add some numbers, though this isn’t necessariy obvious at the time of writing, you aren’t actually drawing meaningfully on the fact that they’re numbers. If that’s the case, then what you can often do is make your code that adds things abstract so you only have to write your program once, but then you can re-use it on all these different other kinds of entities other than numbers.The overall payoff of all that, according to this month’s distinguished guest, is that by following algebra-driven design, you can keep your code simple and easy to understand, while still having it do fancy things. This is particularly important today, when our software just seems to keep getting fancier and fancier, but the usual ways of accomplishing that goal make it unreliable and well nigh impossible to keep up to date.Join us as Gabriella Gonzalez gives us the tour through various algebraic systems that occur all over the place in computer science, philosophy, and linguistics!Matt Teichman Hosted on Acast. See acast.com/privacy for more information.

In this episode, Matt sits down with Gaurav Vankataraman (Trisk Bio) to talk about how human memory is physically realized.Where do your memories live? In the brain, right? They’re, like, imprinted there somehow? We often think of memories as analogous with recordings, like when you do an audio recording and the air vibrations get translated into an electrical signal which reorients the magnetic particles on some tape. But is that really how it works? Is the brain some tape waiting to get recorded to, or a hard drive waiting to get data written to it? We don’t exactly have definitive answers to those questions, but in this episode, our distinguished guest discusses a line of research into whether memories could be stored outside the brain, in RNA. He then notes that there is also a lot of RNA in the human brain itself, which means that a similar mechanism for storing memories could exist there as well.This research, as it turns out, originated in some rather astonishing scientific work from the 1950s involving planarian flatworms. Planarian flatworms have the extraordinary ability to regenerate: if you cut one in half, each of the two halves can actually grow back into a new worm. At that time, there was some preliminary evidence to suggest that if a planarian flatworm learned something, and you cut it in half, when the half that didn’t have a brain grew back, it still retained what the original worm had learned. What the what? It could remember something even though it had a brand new brain? Those initial studies went through a period of being discredited, but in recent years a number of researchers have been exploring new, more rigorous evidence that something of this nature could be going on. Perhaps the flatworms could actually be storing some of their memories in their RNA or DNA, and perhaps RNA has the ability to preserve some of that information both in and outside of the brain.In this episode, Gaurav Venkataraman argues that the RNA in the brain not responsible for making proteins (called non-coding RNA) has a specific type of mathematical structure that is particularly well-suited for transmitting information both fast and accurately. Not only that, but entities with that kind of structure transmit information more accurately the faster they transmit it. So the fact that RNA in the brain is structurally arranged in the way it is actually makes it a viable candidate for being sort of like the brain’s “software” for storing and manipulating memories. Hosted on Acast. See acast.com/privacy for more information.