Knowable

Sloppy by modern standards — and maybe even those back then — a 1955 article on the placebo effect by Harvard anesthesiologist Henry K. Beecher was nonetheless remarkable and influential. It paved the way for sounder drug trials and pushed scientists to better understand how we process pain. To explore its significance, Host Charlotte Stoddart enlisted the help of Ted Kaptchuk, director of the Program in Placebo Studies at the Beth Israel Deaconess Medical Center in Boston, who knows the paper well. Find the transcript and additional resources at knowablemagazine.org/podcast.

The fossil Archaeopteryx forever changed our understanding of dinosaurs and the origin of birds, but it took a century after its discovery and a one-page paper to shift scientific consensus. Here’s the story of that landmark 1973 article by American paleontologist John Ostrom, and published in the journal Nature, describing the bird-like features of Archaeopteryx and convincingly arguing that birds were descended from a group of dinosaurs called theropods. Host Charlotte Stoddart speaks with paleontologist Julia Clarke of the University of Texas at Austin, whose own research focuses on the early evolution of birds and the origin of flight. Find the transcript and additional resources at knowablemagazine.org/podcast.

A key report to President Lyndon B. Johnson in 1965 warned that humankind was “unwittingly conducting a vast geophysical experiment” through the burning of fossil fuels and a consequent buildup of “the invisible pollutant” — carbon dioxide — in the atmosphere. Here’s the story of what happened next to that report — and what didn’t, and why. Host Adam Levy speaks with Harvard science historian Naomi Oreskes, coauthor of the book Merchants of Doubt: How a Handful of Scientists Obscured the Truth on Issues from Tobacco Smoke to Global Warming. And he talks with environmental scientist Dana Nuccitelli, research coordinator for Citizens’ Climate Lobby, which aims to build political will for climate solutions through citizen volunteers.  Find the transcript and additional resources at knowablemagazine.org/podcast

Serendipitous discoveries led to drugs like Prozac and to new insights into the physical basis of this debilitating disorder. But scientists continue to search for deeper understandings and therapies that will bring relief to those who still struggle.