eanCast: Weekly Neurology

• Ep. 144: New Methods to Identify Larger Structural Variants

  Moderator: Maria Judit Molnar (Budapest, Hungary)Guest: Arianna Tucci (London, UK)In this episode Molnar hosts Tucci as they explore how advancements in short- and long-read sequencing technologies are revolutionizing the diagnosis of neurogenetic disorders by uncovering genetic variants previously missed by traditional methods.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely already an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password’-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department ([email protected]) to cross-check if you are listed as an Associate Member to get access to eanCampus.

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• Ep. 143: Novel Aspects of Repeat Expansions in Disease

  Moderator: Francesca Magrinelli (London, UK)Guest: Andrea Cortese (London, UK)Join Magrinelli as she interviews Cortese about recent developments in the diagnosis and management of repeat expansion disorders, including diseases caused by repeats in non-coding genomic regions.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely aleady an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password’-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department ([email protected]) to cross-check if you are listed as an Associate Member to get access to eanCampus.

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• Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease

  Moderator: Jean-Marc Burgunder (Guemligen, Switzerland)Guest: Sandrine Humbert (Paris, France)In this week's episode, Burgunder and Humbert discuss the intriguing phenomenon of somatic expansion—the further increase of CAG repeat numbers in the gene involved in Huntington’s disease, particularly in the striatum. They explore the molecular mechanisms behind this process, as addressed in two recent research papers.Please find here the papers discussed in this episode: Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s diseaseand Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely aleady an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password’-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department ([email protected]) to cross-check if you are listed as an Associate Member to get access to eanCampus.

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• Ep. 141: Sodium Valproate in Men

  EAN moderator: Barbara Tettenborn (St. Gallen, Switzerland)Guest: Tony Marson (Liverpool, UK)In this special episode, Tettenborn and Marson discuss sodium valproate treatment for epilepsy, focusing on its use in men. They try to deemphasize the potential risks of reduced fertility and the lately published potential neurodevelopmental effects on children born to men taking the drug, while also addressing the challenges in balancing treatment effectiveness and safety.

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• Ep. 140: Transition from Childhood to Adulthood​

  Moderator: Gudrun Gröppel​ (Linz, Austria)Guests: Dana Craiu​ (Bucharest, Romania), Thomas Berger​ (Vienna, Austria)This episode explores the challenges and solutions in transitioning young neurology patients from pediatric to adult care. Gröppel, Craiu and Berger discuss the importance of patient education, parental involvement, and collaborative efforts between pediatric and adult neurologists to ensure a smooth transition.If you want to participate in the mentioned survey, please see here: Transition from child to adult care in Pediatric Neurological Disorders in Europe – a joint EAN-EPNS Survey (available until 28 March 2025, 23:59).

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